Research

Head shot2Dr. Telugu has primary appointment with University of Maryland, where he is an Assistant Professor in the Department of Animal and Avian Sciences. He also holds a “Visiting Scientist” appointment with USDA, ARS, Beltsville. The laboratory has two primary research interests, Reproductive Biology and Biotechnology.

A)  Reproductive Biology: The goal here is to investigate early fate determination events leading to the formation placenta, and “primordial germ cells” that give rise to future gametes (Sperm and eggs). Understanding the “normal” developmental events associated with placenta formation will help address pregnancy disorders associated with defective placenta such as preeclampsia, intra-uterine growth retardation and pre-term labor. Likewise, investigating development of Primordial germ cells will provide a basis for addressing male infertility and genetic engineering.

B) Genetic Engineering/ Biotechnology: The laboratory employs site-specific genome editing tools such as CRISPRs and TALENS, and induced pluripotent stem cells (iPSC) for site specifically altering the genome in large animal model pig for biomedical and agricultural applications. Specifically, the goal here is to generate a porcine model of diabetes. Likewise, genome editing tools are employed to alter alleles to facilitate “rational selection” of agricultural traits. For more detailed information, please contact the PI: btelugu@umd.edu or Bhanu.Telugu@ars.usda.gov